Screen Gems debuted the 3-D teaser trailer for Resident Evil: Afterlife to a rowdy, jam-packed audience at the 2010 WonderCon, and the response of the crowd was overwhelmingly positive. Before it'd even finished up, Resident Evil fans were demanding a second showing of the action-packed teaser. And, after a Q&A with writer/director/producer Paul W S Anderson, Milla Jovovich, and Ali Larter, Screen Gems gave in and screened the trailer (which hadn't been seen outside of Anderson's cutting room) to more enthusiastic applause.

This fourth film of the Resident Evil series wasn't converted to 3-D as an afterthought, but instead was conceived in 3-D. Just about a year ago Anderson was invited by James Cameron to see Avatar, and that was when he got the idea to make this Resident Evil the first to be in 3-D. Anderson says he was totally impressed with Cameron's camera system and asked Screen Gems for more money to make Afterlife in Real 3-D.